2018 Research in the Capitol
Synthesis and Coupling Schemes of Naphthalimide Compounds with Target Drugs [Poster]
Presentation Type
Poster Presentation (Electronic Copy Not Available)
Keywords
Drug targeting;
Abstract
The target compound has three major parts, the naphthalimide core with tail, a linker, and the target drug. The target compound can be used for localized drug delivery by utilizing the photoactive properties of the core and a hydrolysis reaction in the body. Our research focused on the synthesis of target compound. There were two reactions schemes used during this research. The original scheme followed steps to synthesize the naphthalimide core with the tail and linker portion of the compound first, then it is coupled with the target drug. The second scheme, or modified scheme, was developed during this project to more effectively synthesize the target product. In the modified scheme, first half of the linker is attached to the naphthalimide core with the tail, then the other half is attached to the target drug, and finally the two halves of the linker are attached.
Start Date
3-4-2018 11:30 AM
End Date
3-4-2018 1:30 PM
Event Host
University Honors Programs, Iowa Regent Universities
Faculty Advisor
Jeff Elbert
Department
Department of Chemistry and Biochemistry
Copyright
©2018 Kaitlyn Parrott
File Format
application/pdf
Recommended Citation
Parrott, Kaitlyn, "Synthesis and Coupling Schemes of Naphthalimide Compounds with Target Drugs [Poster]" (2018). Research in the Capitol. 13.
https://scholarworks.uni.edu/rcapitol/2018/all/13
Synthesis and Coupling Schemes of Naphthalimide Compounds with Target Drugs [Poster]
The target compound has three major parts, the naphthalimide core with tail, a linker, and the target drug. The target compound can be used for localized drug delivery by utilizing the photoactive properties of the core and a hydrolysis reaction in the body. Our research focused on the synthesis of target compound. There were two reactions schemes used during this research. The original scheme followed steps to synthesize the naphthalimide core with the tail and linker portion of the compound first, then it is coupled with the target drug. The second scheme, or modified scheme, was developed during this project to more effectively synthesize the target product. In the modified scheme, first half of the linker is attached to the naphthalimide core with the tail, then the other half is attached to the target drug, and finally the two halves of the linker are attached.
