Synthesis of Estrogenic Isoflavone Derivatives

Authors

Lester Yoder, Iowa Agricultural Experiment StationFollow
Edmund Cheng, Iowa Agricultural Experiment StationFollow
Wise Burroughs, Iowa Agricultural Experiment StationFollow

Document Type

Research

Abstract

Natural estrogens in plants have assumed considerable importance since the demonstration of their presence in subterranean clover by Bennetts (1) in 1946 and the identification of the isoflavone, genistein (V, 4', 5, 7-OH) as the probable substance responsible for some of the estrogenic activity by Curnow and Bennetts (2) in 1952. Earlier the isoflavones were found in soybean meal as genistein glucoside (3) (5), methyl genistein (V, 6',5, 7,-OH,8- CH₃), isogenistein (V,6',5,7-OH), tatoin (V,4',5-OH,8-CH₃) ( 4), daidzein (V,4',7-OH) and formononetin (V,4'-OCH₃,7-OH) (5). Furthermore the isoflavone biochanin A (V, 4'-OCH₃, 5, 7-OH) was isolated from chana seed by Bose and Siddique (6) and formononetin from subterranean clover by Bradbury and White (7).

Publication Date

1954

Journal Title

Proceedings of the Iowa Academy of Science

Volume

61

Issue

1

First Page

271

Last Page

277

Copyright

©1954 Iowa Academy of Science, Inc.

Language

en

File Format

application/pdf

Recommended Citation

Yoder, Lester; Cheng, Edmund; and Burroughs, Wise (1954) "Synthesis of Estrogenic Isoflavone Derivatives," Proceedings of the Iowa Academy of Science, 61(1), 271-277.
Available at: https://scholarworks.uni.edu/pias/vol61/iss1/33