Honors Program Theses

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Open Access Honors Program Thesis

First Advisor

Bart Bergquist

Abstract

Podosomes are actin rich structures found in cancer cells and cells derived from monocytes in the human body. They help these cells be motile through the body and invade through tissues. We found the number of podosomes observed in the cells increased, with a simultaneous increase in motility, corresponding to an increase in the concentration of Epigallocatechin gallate(EGCG) used in a dose-dependent fashion. We also found that the actin molecules in the podosomes are arranged in columns with frequent breaks in its structure. We also found myosin llb to be an integral part of the podosome, providing the podosome with the banding pattern along with actin. We were also able to confirm the presence of gelsolin in the podosome and assembled together a model trying to explain the interaction among all these proteins.

Year of Submission

2009

Department

Department of Biology

University Honors Designation

A thesis submitted in partial fulfillment of the requirements for the designation University Honors

Comments

If you are the rightful copyright holder of this thesis and wish to have it removed from the Open Access Collection, please submit a request to scholarworks@uni.edu and include clear identification of the work, preferably with URL.

Date Original

5-2009

Object Description

1 PDF file (22 pages)

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