Silyation of carbon-hydrogen bonds using diruthenium catalysts
Honors Program Thesis (Electronic Copy Not Available)
Martin Chin, Honors Thesis Advisor, Chemistry and Biochemistry
The silylation of carbon-hydrogen bonds in pyridine can provide a building block that can be then used for further reactions, such as Suzuki coupling reactions. Current methods for C-H bond activation involves the use of toxic molecules. Using silicon to activate C-H bonds is a less toxic method that maintains the desired reactivity. The silylation of pyridine can be done by using diruthenium catalysts, where a hydrogen atom on pyridine is replaced with a silicon atom. This reaction is carried out at 110-220 °C with different diruthenium complexes with 3-silylpyridine as the main product (30-40% yield). Figure 1 shows the desired product. The focus of this research project was to synthesize and characterize the silylated products. The products that were looked at were the reactions using pyridine, 2-picoline, or 4-picoline with triethylsilanes.
Year of Submission
Department of Chemistry and Biochemistry
University Honors Designation
A thesis submitted in partial fulfillment of the requirements for the designation University Honors
1 PDF file (21 pages)
©2019 Joshua Wesley Prybil
Prybil, Joshua Wesley, "Silyation of carbon-hydrogen bonds using diruthenium catalysts" (2019). Honors Program Theses. 380.