Faculty Publications

The Effect Of Chemical Radiation Protectors On Cell Cycle Progression After Gamma Or Neutron Irradiation

Document Type

Article

Journal/Book/Conference Title

Cell Proliferation

Volume

24

Issue

3

First Page

271

Last Page

280

Abstract

Abstract. The effects of two chemical radiation protectors, WR‐1065 and WR‐151326, were characterized in V79 Chinese hamster cells after either cobalt‐60 (60Co) gamma or fission spectrum neutron irradiation. Each protector was administered at a concentration of 4 mM to exponentially growing cultures for 30 min prior to and during irradiation with either 60Co gamma or JANUS fission spectrum neutrons. After irradiation the cells were either plated immediately for survival or returned to the incubator and assayed for cell progression. Aliquots of cells were removed at selected times, counted, fixed and stained with 4'6‐diamidino‐2‐phenylindole (DAPI). Analysis of DNA histograms indicate that the presence of the protector during irradiation reduced the division delay experienced at the G2‐M interface. Implications of these effects are discussed. Copyright © 1991, Wiley Blackwell. All rights reserved

Original Publication Date

1-1-1991

DOI of published version

10.1111/j.1365-2184.1991.tb01156.x

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