Faculty Publications

Eosinophils And Mast Cells In Leishmaniasis

Document Type

Article

Keywords

Eosinophils, Innate immunity, Leishmania, Mast cells

Journal/Book/Conference Title

Immunologic Research

Volume

59

Issue

1-3

First Page

129

Last Page

141

Abstract

Leishmania spp. are parasitic protozoa endemic in tropical and subtropical regions and the causative agent of leishmaniasis, a collection of syndromes whose clinical manifestations vary according to host and pathogen factors. Leishmania spp. are inoculated into the mammalian host by the bite of an infected sand fly, whereupon they are taken up by phagocytosis, convert into the replicative amastigote stage within macrophages, reproduce, spread to new macrophages and cause disease manifestations. A curative response against leishmaniasis depends in the classical activation of macrophages and the IL-12-dependent onset of an adaptive type 1 response characterized by the production of IFN-γ. Emerging evidence suggests that neutrophils, dendritic cells and other immune cells can serve as either temporary or stable hosts for Leishmania spp. Furthermore, it is becoming apparent that the initial interactions of the parasite with resident or early recruited immune cells can shape both the macrophage response and the type of adaptive immune response being induced. In this review, we compile a growing number of studies demonstrating how the earliest interactions of Leishmania spp. with eosinophils and mast cells influence the macrophage response to infection and the development of the adaptive immune response, hence, determining the ultimate outcome of infection. © 2014 Springer Science+Business Media.

Department

Department of Biology

Original Publication Date

1-1-2014

DOI of published version

10.1007/s12026-014-8536-x

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