Dissertations and Theses @ UNI
Availability
Open Access Thesis
Keywords
Calcification; Calciphylaxis; Rats--Physiology;
Abstract
Calciphylactic nephrocalcinosis was induced in female Sprague Dawley rats by treatment with dihydrotachysterol (0.5 mg/100g body weight) and thallous acetate (2 mg/100 g body weight). A calcium-phosphatephospholipid complex was isolated from rat kidneys exhibiting calciphylactic nephrocalcinosis and from untreated controls. There was a statistically significant greater quantity of complex extractable after calciphylaxis was induced. An average of 8.0% of the total phospholipid extracted from the tissue was present in complexed form in treated animals and 3.7 % in control animals. The phospholipid component of the complex was identified as phosphatidyl serine. The ratio of calcium to phosphate was less than 0.5, which is similar to the ratio reported in the literature for a calcium-phosphatephospholipid complex isolated from tumors but dissimilar to the ratio of unity reported for a complex isolated from normally calcified tissues. The significance of the calcium-phosphate-phospholipid complex in calcifying tissue is discussed and a possible mechanism for calciphylactic nephrocalcinosis is presented.
Year of Submission
1982
Degree Name
Master of Arts
Department
Department of Biology
First Advisor
Robert J. Simpson
Second Advisor
Robert Gross
Third Advisor
Alan R. Orr
Date Original
1982
Object Description
1 PDF file (133 leaves)
Copyright
©1982 Elaine Bardes Haynes
Language
en
File Format
application/pdf
Recommended Citation
Haynes, Elaine Bardes, "A Calcium-Phosphate-Phospholipid Complex Extracted From Rats Exhibiting Calciphylactic Nephrocalcinosis" (1982). Dissertations and Theses @ UNI. 2911.
https://scholarworks.uni.edu/etd/2911
Comments
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