Faculty Publications

Document Type

Article

Keywords

Cadherin, Chick embryo, Organogenesis, Immunolocalization, In situ hybridization, Secondary neurulation

Journal/Book/Conference Title

International Journal of Biology

Volume

4

Issue

1

First Page

36

Last Page

48

Abstract

Cadherin-11 (cad-11) is primarily a mesenchymal cadherin that appears in delaminating neural crest cells. Its expression correlates with morphogenetic events and the pattern has been studied in mouse, rat and Xenopus embryos, but not during avian organogenesis. Our purpose was to investigate this pattern in the chick embryo during organogenesis using immunolocalization and in situ hybridization. Cad-11 was expressed in mesenchyme around the pharynx and aortic arches, eyes, auditory vesicles, lung buds, stomach, and nasal placodes. Neural expression included some cranial ganglia and also new neuroepithelium within the tail bud region undergoing secondary neurulation. We also found expression in epithelia of the developing circulatory and digestive organs. The limb buds, pineal rudiment and mesonephros were also positive. Cad-11 expression became more widespread with development. Our findings support the role of cad-11 as a mesenchymal cadherin, but provide evidence for a wider role that includes epithelial morphogenesis and secondary neurulation.

Department

Department of Biology

Comments

First published in International Journal of Biology, v. 4 n. 1 (2012), pp. 36-48, published by Canadian Center of Science and Education. DOI: http://dx.doi.org/10.5539/ijb.v4n1p36

Original Publication Date

2012

DOI of published version

http://dx.doi.org/10.5539/ijb.v4n1p36

Repository

UNI ScholarWorks, University of Northern Iowa, Rod Library

Date Digital

2012

Copyright

©2012 Canadian Center of Science and Education. The copyright holder has granted permission for posting.

Language

EN

File Format

application/pdf

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