2022 Summer Undergraduate Research Program (SURP) Symposium

Location

ScholarSpace, Rod Library, University of Northern Iowa

Presentation Type

Poster Presentation (UNI Access Only)

Document Type

poster

Abstract

  • The goal of this research project is to design a stochastic Monte Carlo model on the competition between nucleoproteins RAD51 and Replication Protein A (RPA) during the DNA repair process known as Homologous Recombination.
  • Due to the nucleoproteins affinity for single-stranded DNA, we see RPA and RAD51 compete for binding space on a single overhang. This binding process is assisted by mediator proteins that prevent RPA, the protein with a higher binding affinity, from oversaturating the DNA strand.
  • Homologous repair is a DNA repair process that repairs breaks in double-stranded DNA using like genetic material from similar DNA strands

Start Date

29-7-2022 11:00 AM

End Date

29-7-2022 1:30 PM

Event Host

Summer Undergraduate Research Program, University of Northern Iowa

Faculty Advisor

Ali Tabei

Department

Department of Physics

File Format

application/pdf

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Jul 29th, 11:00 AM Jul 29th, 1:30 PM

Nucleoprotein Competition on ssDNA: Stochastic Monte Carlo Model

ScholarSpace, Rod Library, University of Northern Iowa

  • The goal of this research project is to design a stochastic Monte Carlo model on the competition between nucleoproteins RAD51 and Replication Protein A (RPA) during the DNA repair process known as Homologous Recombination.
  • Due to the nucleoproteins affinity for single-stranded DNA, we see RPA and RAD51 compete for binding space on a single overhang. This binding process is assisted by mediator proteins that prevent RPA, the protein with a higher binding affinity, from oversaturating the DNA strand.
  • Homologous repair is a DNA repair process that repairs breaks in double-stranded DNA using like genetic material from similar DNA strands