UNI ScholarWorks - Summer Undergraduate Research Program (SURP) Symposium: Nucleoprotein Competition on ssDNA: Stochastic Monte Carlo Model
 

2022 Summer Undergraduate Research Program (SURP) Symposium

Location

ScholarSpace, Rod Library, University of Northern Iowa

Presentation Type

Poster Presentation (UNI Access Only)

Document Type

poster

Keywords

Nucleoproteins--Mathematical models; DNA repair--Mathematical models;

Abstract

  • The goal of this research project is to design a stochastic Monte Carlo model on the competition between nucleoproteins RAD51 and Replication Protein A (RPA) during the DNA repair process known as Homologous Recombination.
  • Due to the nucleoproteins affinity for single-stranded DNA, we see RPA and RAD51 compete for binding space on a single overhang. This binding process is assisted by mediator proteins that prevent RPA, the protein with a higher binding affinity, from oversaturating the DNA strand.
  • Homologous repair is a DNA repair process that repairs breaks in double-stranded DNA using like genetic material from similar DNA strands

Start Date

29-7-2022 11:00 AM

End Date

29-7-2022 1:30 PM

Event Host

Summer Undergraduate Research Program, University of Northern Iowa

Faculty Advisor

Ali Tabei

Department

Department of Physics

File Format

application/pdf

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Jul 29th, 11:00 AM Jul 29th, 1:30 PM

Nucleoprotein Competition on ssDNA: Stochastic Monte Carlo Model

ScholarSpace, Rod Library, University of Northern Iowa

  • The goal of this research project is to design a stochastic Monte Carlo model on the competition between nucleoproteins RAD51 and Replication Protein A (RPA) during the DNA repair process known as Homologous Recombination.
  • Due to the nucleoproteins affinity for single-stranded DNA, we see RPA and RAD51 compete for binding space on a single overhang. This binding process is assisted by mediator proteins that prevent RPA, the protein with a higher binding affinity, from oversaturating the DNA strand.
  • Homologous repair is a DNA repair process that repairs breaks in double-stranded DNA using like genetic material from similar DNA strands