Presidential Scholars Theses (1990 – 2006)

Awards/Availabilty

Open Access Presidential Scholars Thesis

First Advisor

Darrell Weins

Abstract

Fibronectin is believed to play a directional role in the migration of precardiac mesodermal cells and m~y be involved in other aspects of cardiogenesis. In this study we investigated the role of fibronectin in the development development of heart beat by employing a chick precardiac explant culture system. Fibronectin is recognized by an integrin receptor molecule via an RGD amino acid sequence. Using a synthetic RGD peptide we have blocked the ability of any existing receptor molecules to interact with fibronectin in an attempt to break communication of the mesodermal cells with the extracellular environment. Explanted tissues treated with this blocking agent failed to form contracting vesicles in vitro in a dose-dependent manner. This evidence suggests a role for fibronectin in precardiac cell differentiation and development.

Date of Award

1991

Department

Department of Biology

Presidential Scholar Designation

A paper submitted in partial fulfillment of the requirements for the designation Presidential Scholar

Comments

If you are the rightful copyright holder of this Presidential Scholars thesis and wish to have it removed from the Open Access Collection, please submit an email request to scholarworks@uni.edu. Include your name and clearly identify the thesis by full title and author as shown on the work.

Date Original

5-1-1991

Object Description

1 PDF (14 pages)

Date Digital

4-3-2018

Copyright

©1991 W. Kimryn Rathmell

Type

document

Language

EN

File Format

application_pdf

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