Presidential Scholars Theses (1990 – 2006)
Awards/Availabilty
Open Access Presidential Scholars Thesis
First Advisor
Darrell Weins
Keywords
Fibronectins; Cell migration; Heart--Contraction; Chickens--Embryos;
Abstract
Fibronectin is believed to play a directional role in the migration of precardiac mesodermal cells and m~y be involved in other aspects of cardiogenesis. In this study we investigated the role of fibronectin in the development development of heart beat by employing a chick precardiac explant culture system. Fibronectin is recognized by an integrin receptor molecule via an RGD amino acid sequence. Using a synthetic RGD peptide we have blocked the ability of any existing receptor molecules to interact with fibronectin in an attempt to break communication of the mesodermal cells with the extracellular environment. Explanted tissues treated with this blocking agent failed to form contracting vesicles in vitro in a dose-dependent manner. This evidence suggests a role for fibronectin in precardiac cell differentiation and development.
Date of Award
1991
Department
Department of Biology
Presidential Scholar Designation
A paper submitted in partial fulfillment of the requirements for the designation Presidential Scholar
Date Original
5-1-1991
Object Description
1 PDF file (14 pages)
Date Digital
4-3-2018
Copyright
©1991 W. Kimryn Rathmell
Type
document
Language
en
File Format
application_pdf
Recommended Citation
Rathmell, W. Kimryn, "A role for fibronectin in the development of beat in chick embryo cardiogenesis" (1991). Presidential Scholars Theses (1990 – 2006). 128.
https://scholarworks.uni.edu/pst/128
Comments
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