Effects of Estrogen and Progesterone on Serum Ionized and Total Calcium in Ovariectomized Rats

Authors

Edward L. Hatcher, University of Northern Iowa
Robert J. Simpson, University of Northern IowaFollow

Document Type

Research

Keywords

Total Serum Calcium, Ionized Serum Calcium, Estrogen, Progesterone, Ovariectomy, Rats

Abstract

The effects of estrogen and estrogen plus progesterone on the serum ionized calcium levels were studied in ovariectomized rats. Concentrations of total and ionized calcium were measured in the serum of rats following three- and six-day treatments with estrogen (01μg daily). Concentrations of ionized calcium in estrogen- treated ovariectomized rats were significantly higher than in controls and significantly higher values were noted in the ionized: total serum calcium ratios in estrogen treated rats as compared with controls. The addition of progesterone to the estrogen treatment procedure resulted in increased total and ionized serum calcium with the ionized values remaining significantly higher than in the ovariectomized controls. The results clearly indicate an estrogenic effect on calcium metabolism resulting in a significant increase in the ionized serum calcium. Suggested possible estrogen and progesterone mechanisms of action are given.

Publication Date

June 1974

Journal Title

Proceedings of the Iowa Academy of Science

Volume

81

Issue

2

First Page

68

Last Page

71

Copyright

©1974 Iowa Academy of Science, Inc.

Language

en

File Format

application/pdf

Recommended Citation

Hatcher, Edward L. and Simpson, Robert J. (1974) "Effects of Estrogen and Progesterone on Serum Ionized and Total Calcium in Ovariectomized Rats," Proceedings of the Iowa Academy of Science, 81(2), 68-71.
Available at: https://scholarworks.uni.edu/pias/vol81/iss2/8