White mice of varying ages were given a definite amount of the tranquilizer, reserpine, over a three-week period. At the end of this period, respiration rates were determined by use of a physiograph with impedance pneumograph and small animal attachments. Mice were given, in addition to the tranquilizer, varying dosages of different medicinals, and their respiratory pattern was recorded. Such medicinals as thyroxin, streptomycin, vitamins E and C were given and in combination with sulfanilamide, nicotinamide, neonal, kayquinone, hykenone. Effects of multiple medications were noted and recorded. Reserpine, when given in all combinations, lowered the respiratory rate from that recorded when each drug was given alone. Vitamin C gave a stabilizing effect to the respiratory pattern when given in combination with other medications.
Proceedings of the Iowa Academy of Science
©1967 Iowa Academy of Science, Inc.
Shell, Lester C.; Burdick, Judith A.; and Wilson, Kenneth
"Effects of Medication on Respiration Pattern of Tranquilized White Mice,"
Proceedings of the Iowa Academy of Science, 74(1), 218-221.
Available at: https://scholarworks.uni.edu/pias/vol74/iss1/35