Relative Mitochondrial Volume in Liver Cells of A/Jax Mice Under Influence of Carbon Tetrachloride

Authors

Jim N. Tone, Iowa State University
Leland P. Johnson, Drake UniversityFollow

Document Type

Research

Abstract

The purpose of this study was to determine the relative volume of mitochondria in situ in hepatic cells adjacent to the interlobular veins in the livers of normal A-Jax mice and of A-Jax mice fed carbon tetrachloride dosages for varying periods of time. The liver tissues were fixed in Regaud's fluid, sectioned at 3 microns, and stained with iron haematoxylin. A procedure developed by Meglitsch et al. was utilized in determining the relative mitochondrial volume of the hepatic cells. The following were determined in the study: (1) normal mice older than six weeks possessed a greater relative mitochondrial volume in both the peripheral and basal regions of the median layer liver lobe than six-week normal mice, and (2) the relative mitochondrial volume of hepatic cells of A/Jax mice fed carbon tetrachloride was significantly less than normal mice of similar age.

Publication Date

1963

Journal Title

Proceedings of the Iowa Academy of Science

Volume

70

Issue

1

First Page

458

Last Page

465

Copyright

©1963 Iowa Academy of Science, Inc.

Language

en

File Format

application/pdf

Recommended Citation

Tone, Jim N. and Johnson, Leland P. (1963) "Relative Mitochondrial Volume in Liver Cells of A/Jax Mice Under Influence of Carbon Tetrachloride," Proceedings of the Iowa Academy of Science, 70(1), 458-465.
Available at: https://scholarworks.uni.edu/pias/vol70/iss1/74