Document Type



The proportion of the cell populations composed of parenchymal, littoral, and other types of cells is reported for control mice, mice repeatedly anesthetized, mice fed with olive oil repeatedly, and mice fed with carbon tetrachloride and olive oil, showing that the cellular components undergo a marked change when carbon tetrachloride is administered. The proportion of the liver volume occupied by parenchymal cells is found to be relatively stable throughout the period of tumor induction. The nuclear-cytoplasmic ratio of parenchymal cells is found to fall with the aging of control mice and those fed olive oil or anesthetized during the period of the experiment. The nuclear-cytoplasmic ratio is found to fall to a minimal point during the first two weeks of carbon tetrachloride feeding, thereafter gradually rising to normal values for mice of the same age, and eventually rising, after 24 feedings, to a value exceeding that of normal mice of the same age. Between 24 and 30 feedings the nuclear-cytoplasmic ratio undergoes a decrease. The volumes of parenchymal cell nuclei are found to vary with the position in a lobule, the maximal nuclear volumes being found in a region about 100μ to 200μ from the central vein in lobules of average size.

Publication Date


Journal Title

Proceedings of the Iowa Academy of Science





First Page


Last Page



©1960 Iowa Academy of Science, Inc.



File Format




To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.