Several workers (Greenspan et al., 1950; Reinhardt and Li, 1951; Stack-Dunne and Young, 1951) have reported a lack of correlation between the eosinopenic, adrenal ascorbic acid lowering activity, and maintenance of adrenal weights with various adrenocorticotrophic preparations. Reinhardt et al. (1951) have critically evaluated assay methods for adrenocorticotrophic hormone (ACTH) and cautioned that differences in rate of absorption, variations in route of administration and dose-time-response relationships may influence the results obtained with different testing procedures. The study reported here was conducted under standardized conditions to determine whether the route of administration would influence the eosinopenic and adrenal ascorbic acid depleting properties of two ACTH preparations.
Proceedings of the Iowa Academy of Science
©1956 Iowa Academy of Science, Inc.
Giere, Frederic A. and Eversole, W. J.
"Adrenal Ascorbic Acid Depletion Without Eosinopenia in Hypophysectomized Rats Injected lntrasplenically with Corticotrophin,"
Proceedings of the Iowa Academy of Science, 63(1), 693-696.
Available at: https://scholarworks.uni.edu/pias/vol63/iss1/78