During the period of development of salicylate therapy, it was demonstrated that many body membranes were permeable to salicylates, and that appreciable quantities were excreted in the urine. With the development of a satisfactory quantitative method by Brodie et al. (1) the salicylate concentration in body fluids and urine could be determined. More recently the successful labelling of salicylates with C14 has placed investigation of salicylate distribution in animal tissues on a more practical basis. The carboxyl group of salicylic acid (2) (3) (4) and the acetyl group of acetylsalicylic acid (5) have been tagged with radioactive carbon. These labelled compounds have been employed in experiments on the metabolism and distribution of the salicylates (3) (4) (6). The most complete distribution study was performed by Schayer (3) after the administration of C11 carboxyl labelled salicylic acid to rats. He determined the radioactivity in various organs and the excretory products 24 hours after administration. Since Schayer found that practically all of the administered salicylate was excreted in 24 hours, it was thought that a shorter period should be employed in such studies. Preliminary experiments indicated that a three hour period would be satisfactory. The following study was undertaken to compare the distribution of carboxyl labelled salicylic acid and acetyl labelled acetylsalicylic acid in body fluids and tissues of rats.
Proceedings of the Iowa Academy of Science
©1956 Iowa Academy of Science, Inc.
Burnham, Esther M.; Paul, W. D.; and Routh, J. I.
"The Distribution of C14 Labelled Salicylates in Rat Tissues,"
Proceedings of the Iowa Academy of Science, 63(1), 403-409.
Available at: https://scholarworks.uni.edu/pias/vol63/iss1/38