Thiouracil, a heterocyclic derivative of thiourea related to pyrimidine, has been found to have certain goitrogenic effects as well as various other bodily effects on laboratory animals treated with the substance. The goitrogenic effects are inhibition of active thyroid hormone formation and a stimulation of gland growth. Inhibition of hormone formation is believed to be due to the combination of thiouracil with iodine (Miller, Roblin, and Astwood, 1945), and, as has been suggested, the drug may act as an antivitamin or antibiotic, since its toxic reactions are similar to those of sulfanilamide, another antivitamin (Laufer and Stewart, 1947). Stimulation of gland growth is a response to excessive secretion of thyrotropic hormone (Mackenzie and Mackenzie, 1943; Astwood et al., 1943). Morphological changes are hypertrophy and hyperplasia of the acinar cells, increased size and weight, loss of follicular colloid, increased height of the acinar epithelium, and marked hyperemia.
Proceedings of the Iowa Academy of Science
©1950 Iowa Academy of Science, Inc.
Shepherd, Ralph H.
"The Effect of Thiouracil on the Golgi Apparatus of the Thyroid Gland in the White Rat,"
Proceedings of the Iowa Academy of Science, 57(1), 505-510.
Available at: https://scholarworks.uni.edu/pias/vol57/iss1/73