Home > Iowa Academy of Science > Journals & Newsletters > Proceedings of the Iowa Academy of Science > Volume 57 (1950) > Annual Issue
Document Type
Research
Abstract
Thiouracil, a heterocyclic derivative of thiourea related to pyrimidine, has been found to have certain goitrogenic effects as well as various other bodily effects on laboratory animals treated with the substance. The goitrogenic effects are inhibition of active thyroid hormone formation and a stimulation of gland growth. Inhibition of hormone formation is believed to be due to the combination of thiouracil with iodine (Miller, Roblin, and Astwood, 1945), and, as has been suggested, the drug may act as an antivitamin or antibiotic, since its toxic reactions are similar to those of sulfanilamide, another antivitamin (Laufer and Stewart, 1947). Stimulation of gland growth is a response to excessive secretion of thyrotropic hormone (Mackenzie and Mackenzie, 1943; Astwood et al., 1943). Morphological changes are hypertrophy and hyperplasia of the acinar cells, increased size and weight, loss of follicular colloid, increased height of the acinar epithelium, and marked hyperemia.
Publication Date
1950
Journal Title
Proceedings of the Iowa Academy of Science
Volume
57
Issue
1
First Page
505
Last Page
510
Copyright
©1950 Iowa Academy of Science, Inc.
Language
en
File Format
application/pdf
Recommended Citation
Shepherd, Ralph H.
(1949)
"The Effect of Thiouracil on the Golgi Apparatus of the Thyroid Gland in the White Rat,"
Proceedings of the Iowa Academy of Science, 57(1), 505-510.
Available at:
https://scholarworks.uni.edu/pias/vol57/iss1/73