Patents (University of Northern Iowa)
Document Type
Patent
Publication Date
12-25-1984
Patent Number
4490543
Abstract
Bis(5-aminofluorescein)dichloroplatinum(II), and substituted fluoresceinamine derivatives of this compound are disclosed as highly effective radiation sensitizers which enhance the effect of ionizing radiation on tumor cells, but uniquely do so without the usual accompanying high toxicity level to surrounding normal cells. A direct combination, single step reaction synthesis is disclosed for preparing bis(5-aminofluorescein)dichloroplatinum(II) from the reaction between an alkali metal tetrachloroplatinate(II) and 5-aminofluorescein.
Application Number
4490543
Assignee
University of Northern Iowa Foundation
Assignee City
Cedar Falls
Assignee State
Iowa
Assignee Country
United States
Filing Date
11-12-1982
Language
en
Recommended Citation
Bergquist, Barton L. and Chang, James C., "Low toxicity radiation sensitizer" (1984). Patents (University of Northern Iowa). 21.
https://scholarworks.uni.edu/patents/21
