Low toxicity radiation sensitizer

Inventor

Barton L. BergquistFollow
James C. Chang, University of Northern IowaFollow

Document Type

Patent

Publication Date

12-25-1984

Patent Number

4490543

Abstract

Bis(5-aminofluorescein)dichloroplatinum(II), and substituted fluoresceinamine derivatives of this compound are disclosed as highly effective radiation sensitizers which enhance the effect of ionizing radiation on tumor cells, but uniquely do so without the usual accompanying high toxicity level to surrounding normal cells. A direct combination, single step reaction synthesis is disclosed for preparing bis(5-aminofluorescein)dichloroplatinum(II) from the reaction between an alkali metal tetrachloroplatinate(II) and 5-aminofluorescein.

Application Number

4490543

Assignee

University of Northern Iowa Foundation

Assignee City

Cedar Falls

Assignee State

Iowa

Assignee Country

United States

Filing Date

11-12-1982

Language

en

Recommended Citation

Bergquist, Barton L. and Chang, James C., "Low toxicity radiation sensitizer" (1984). Patents (University of Northern Iowa). 21.
https://scholarworks.uni.edu/patents/21