Honors Program Theses


Open Access Honors Program Thesis

First Advisor

Ira Simet


Replicative DNA polymerases are enzymes located in the nuclei of cells. They have a role in the control of DNA synthesis in all cells, and problems with their function and control affect cell growth. One of these polymerases, DNA polymerase alpha ("pol α"), is a possible point of control for cell growth because it initiates DNA synthesis. The ability to selectively turn on or shut off this polymerase in cells could provide answers to problems ranging from cancer's unregulated growth to regeneration of tissues. However, control mechanisms for DNA pol α are not fully understood at this time. The central theme to be addressed is to learn more about the growth-related transcriptional control of DNA pol α. This project is the preliminary step looking into DNA pol α in embryonic chicken brain. Our approach is to quantify the amount of mRNA for the DNA pol α catalytic subunit in embryonic chicken brain cells at different developmental stag

Year of Submission



Department of Chemistry and Biochemistry

University Honors Designation

A thesis submitted in partial fulfillment of the requirements for the designation University Honors


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Date Original


Object Description

1 PDF file (27 pages)