Honors Program Theses

Award/Availability

Open Access Honors Program Thesis

First Advisor

Ira Simet

Abstract

Replicative DNA polymerases are enzymes located in the nuclei of cells. They have a role in the control of DNA synthesis in all cells, and problems with their function and control affect cell growth. One of these polymerases, DNA polymerase alpha ("pol α"), is a possible point of control for cell growth because it initiates DNA synthesis. The ability to selectively turn on or shut off this polymerase in cells could provide answers to problems ranging from cancer's unregulated growth to regeneration of tissues. However, control mechanisms for DNA pol α are not fully understood at this time. The central theme to be addressed is to learn more about the growth-related transcriptional control of DNA pol α. This project is the preliminary step looking into DNA pol α in embryonic chicken brain. Our approach is to quantify the amount of mRNA for the DNA pol α catalytic subunit in embryonic chicken brain cells at different developmental stag

Year of Submission

2013

Department

Department of Chemistry and Biochemistry

University Honors Designation

A thesis submitted in partial fulfillment of the requirements for the designation University Honors

Comments

If you are the rightful copyright holder of this thesis and wish to have it removed from the Open Access Collection, please submit a request to scholarworks@uni.edu and include clear identification of the work, preferably with URL.

Date Original

5-2013

Object Description

1 PDF file (27 pages)

Download

Comments?

Share

COinS