Open Access Honors Program Thesis
Melisa M. Cherney
Cytochrome C; Ligand binding (Biochemistry); Protein binding;
The purpose of this research was to create a simpler model of Type II proteins in order to study the ligand switch using cytochrome c (Figure 3). Cytochrome c was chosen because it is small, easy to work with, and relatively easy to mutate. It also already has a built-in mechanism for a ligand switch, making it the ideal candidate for this protein model. Mutating cytochrome c into a model Type II protein and learning more about how the ligand switch controls function may generate new insight into how the corresponding ligand switch works in more complex proteins.
Year of Submission
Department of Chemistry and Biochemistry
University Honors Designation
A thesis submitted in partial fulfillment of the requirements for the designation University Honors
1 PDF file (49 pages)
© 2013 Lindsey M. Ludwig
Ludwig, Lindsey M., "Generating new Type II protein models using cytochrome c" (2013). Honors Program Theses. 48.