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Faculty Publications
Epidemiological And Experimental Evidence For Sex-Dependent Differences In The Outcome Of Leishmania Infantum Infection
Document Type
Article
Journal/Book/Conference Title
American Journal of Tropical Medicine and Hygiene
Volume
98
Issue
1
First Page
142
Last Page
145
Abstract
Leishmania infantum causes visceral leishmaniasis (VL) in Brazil. We previously observed that VL is more common in males than females living in endemic neighborhoods, despite similar exposure. Using a larger sample, we document that VL is more common in males than females, but only after puberty. BALB/c and C57BL/6 mouse models confirmed that there is a biological basis for male susceptibility to symptomatic VL, showing higher parasite burdens in males than females. Female C57BL/6 mice generated more antigen-induced cytokines associated with curative responses (interferon-ã, interleukin [IL]-1β). Males expressed higher levels of IL-10 and tumor necrosis factor, which are linked to exacerbated disease. Different parasite lines entered or survived at a higher rate in macrophages of male-than female-origin. These results suggest that males are inherently more susceptible to L. infantum than females and that mice are a valid model to study this sex-dependent difference.
Department
Department of Biology
Original Publication Date
1-1-2018
DOI of published version
10.4269/ajtmh.17-0563
Repository
UNI ScholarWorks, Rod Library, University of Northern Iowa
Language
en
Recommended Citation
Rodriguez, Nilda E.; Lima, Iraci D.; Dixit, Upasna Gaur; Turcotte, Elizabeth A.; Lockard, Ryan D.; Batra-Sharma, Hemali; Nascimento, Eliana L.; Jeronimo, Selma M.B.; and Wilson, Mary E., "Epidemiological And Experimental Evidence For Sex-Dependent Differences In The Outcome Of Leishmania Infantum Infection" (2018). Faculty Publications. 803.
https://scholarworks.uni.edu/facpub/803