Faculty Publications

Anti-HIV Michellamines from Ancistrocladus korupensis

Document Type

Article

Journal/Book/Conference Title

Journal of Medicinal Chemistry

Volume

37

Issue

12

First Page

1740

Last Page

1745

Abstract

Here we report details of the isolation and determination of the absolute configurations and comparative anti-HIV activities of novel, atropisomeric naphthylisoquinoline alkaloid dimers, michellamines A, B, and C, from a newly described species of Ancistrocladus from the Korup rainforest of Cameroon. We further provide a more extensive analysis of the range of anti-HIV activity of michellamine B, the most potent and abundant member of the series. Michellamine B inhibited HIV-induced cell killing and viral replication in a variety of human cell lines, as well as in cultures of human peripheral blood leukocytes and monocytes. Michellamine B was active against a panel of biologically diverse laboratory and clinical strains of HIV-1, including the AZTresistant strain G910-6 and the pyridinone-resistant strain A17; the compound also inhibited several strains of HIV-2. © 1994, American Chemical Society. All rights reserved.

Department

Department of Chemistry and Biochemistry

Original Publication Date

6-1-1994

DOI of published version

10.1021/jm00038a003

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