Faculty Publications
An Assay that Predicts In Vivo Efficacy for DNA Aptamers that Stimulate Remyelination in a Mouse Model of Multiple Sclerosis
Document Type
Article
Keywords
aptamer, multiple sclerosis, myelin, oligodendrocyte, regeneration
Journal/Book/Conference Title
Molecular Therapy Methods and Clinical Development
Volume
9
First Page
270
Last Page
277
Abstract
Multiple sclerosis (MS) is a debilitating disease for which regenerative therapies are sought. We have previously described human antibodies and DNA aptamer-streptavidin conjugates that promote remyelination after systemic injection into mice infected by Theiler's murine encephalomyelitis virus. Here, we report an in vitro assay of myelin binding with results that correlate with remyelination outcome in vivo, as shown for data from a set of DNA aptamer complexes of different size and formulation. This in vitro assay will be valuable for future screening of MS regenerative therapies targeting remyelination.
Department
Department of Chemistry and Biochemistry
Original Publication Date
6-15-2018
DOI of published version
10.1016/j.omtm.2018.03.005
Recommended Citation
Peters, Justin P.; Heider, Robin M.; Smestad, John A.; Lemus, Hernan Nicolas; Wilbanks, Brandon; Warrington, Arthur E.; Rodriguez, Moses; and Maher, L. James, "An Assay that Predicts In Vivo Efficacy for DNA Aptamers that Stimulate Remyelination in a Mouse Model of Multiple Sclerosis" (2018). Faculty Publications. 6237.
https://scholarworks.uni.edu/facpub/6237
