Faculty Publications
Cellular Uptake And Toxicity Study Of Cis-Bis(6-Aminoquinoline) Dichloroplatinum(II)
Document Type
Article
Journal/Book/Conference Title
Journal of Inorganic Biochemistry
Volume
42
Issue
4
First Page
231
Last Page
235
Abstract
A fluorescent analog of cis-diamminedichloroplatinum(II), cis-bis(6-aminoquinoline)dichloroplatinum(II), was prepared from K2[PtCl4] and 6-aminoquinoline (AQL). HPLC of the thiourea derivative of the new complex showed that it has the cis-configuration. The Pt-AQL complex and the parent ligand AQL were evaluated for biological activity and cellular uptake, using the ciliate Tetrahymena pigmentosa. The complex was relatively nontoxic at the tested levels below 5 × 10-4 M, but did exhibit inhibition of culture growth at 5 × 10-4 M. Measurement of cellular uptake of the Pt-AQL complex demonstrated incorporation into the cell, with localization primarily within the vacuoles of the cells. Comparable measurement of the parent ligand AQL showed little measurable cellular uptake. © 1991.
Department
Department of Biology
Original Publication Date
1-1-1991
DOI of published version
10.1016/0162-0134(91)84037-A
Recommended Citation
Lu, Meiqing; Bergquist, Barton L.; and Chang, James C., "Cellular Uptake And Toxicity Study Of Cis-Bis(6-Aminoquinoline) Dichloroplatinum(II)" (1991). Faculty Publications. 4578.
https://scholarworks.uni.edu/facpub/4578
