Faculty Publications
Michellamines D-F, New HIV-Inhibitory Dimeric Naphthylisoquinoline Alkaloids, And Korupensamine E, A New Antimalarial Monomer, From Ancistrocladus Korupensis
Document Type
Article
Journal/Book/Conference Title
Journal of Natural Products
Volume
60
Issue
7
First Page
677
Last Page
683
Abstract
New monomeric (korupensamine E, 6) and dimeric (michellamines D-F, 7-9) naphthylisoquinoline alkaloids have been isolated from extracts of the tropical liana Ancistrocladus korupensis. Structures were determined by spectroanalytical methods, and stereochemistry was defined through NOE correlations, chemical degradation, and CD spectroscopy. Michellamines D-F exhibited in vitro HIV-inhibitory activity comparable to michellamine B, and korupensamine E exhibited in vitro antimalarial activity comparable to korupensamines A-D.
Department
Department of Chemistry
Original Publication Date
7-1-1997
DOI of published version
10.1021/np9700679
Recommended Citation
Hallock, Yali F.; Manfredi, Kirk P.; Dai, Jin Rui; Cardellina, John H.; Gulakowski, Robert J.; McMahon, James B.; Schäffer, Manuela; Stahl, Martin; Gulden, Klaus Peter; Bringmann, Gerhard; François, Guido; and Boyd, Michael R., "Michellamines D-F, New HIV-Inhibitory Dimeric Naphthylisoquinoline Alkaloids, And Korupensamine E, A New Antimalarial Monomer, From Ancistrocladus Korupensis" (1997). Faculty Publications. 3982.
https://scholarworks.uni.edu/facpub/3982
