Isolation Of An Anti-HIV Diprenylated Bibenzyl From Glycyrrhiza Lepidota

Authors

Kirk P. Manfredi, University of Northern IowaFollow
Vasanti Vallurupalli, University of Northern Iowa
Maria Demidova, University of Northern Iowa
Kelly Kindscher, University of KansasFollow
Lewis K. Pannell, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Follow

Document Type

Article

Keywords

Fabaceae, Glepidotin, Glycyrrhiza lepidota, HIV-1, Prenylated

Journal/Book/Conference Title

Phytochemistry

Volume

58

Issue

1

First Page

153

Last Page

157

Abstract

The organic soluble extract from the leaves of Glycyrrhiza lepidota showed moderate activity in the US National Cancer Institute in vitro anti-HIV-1 bioassay. Chromatographic separation of this extract resulted in the identification of a new diprenylated bibenzyl as the compound responsible for the observed anti-viral activity. Extensive spectroscopic experiments provide the complete 1H NMR and 13C NMR spectral assignments to support the proposed structure. Known compounds glepidotin B and glepidotin A were also isolated from the extract and shown to be inactive in the anti-viral assay. © 2001 Elsevier Science Ltd.

Department

Department of Chemistry

Original Publication Date

8-10-2001

DOI of published version

10.1016/S0031-9422(01)00177-7

Recommended Citation

Manfredi, Kirk P.; Vallurupalli, Vasanti; Demidova, Maria; Kindscher, Kelly; and Pannell, Lewis K., "Isolation Of An Anti-HIV Diprenylated Bibenzyl From Glycyrrhiza Lepidota" (2001). Faculty Publications. 3508.
https://scholarworks.uni.edu/facpub/3508