Faculty Publications

What Is The Relationship Between Myocardial Perfusion Imaging And Coronary Artery Disease Risk Factors And Markers Of Inflammation?

Document Type

Article

Keywords

CVD risk factors, Inflammation and coronary artery disease, Lipids, Myocardial perfusion imaging (MPI)

Journal/Book/Conference Title

Angiology

Volume

59

Issue

1

First Page

16

Last Page

25

Abstract

The treatment of coronary artery disease (CAD) is clinically measured by monitoring changes in venous lipids and inflammatory markers. There is currently no established quantified relationship between coronary flow reserve and markers of inflammatory CAD. A total of 120 men and women underwent quantified measurement of coronary blood flow using SPECT imaging at baseline and 1 year later. They had fasting venous blood work obtained at baseline and 1 year later. These markers of lipids and inflammation included, total cholesterol, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, lipoprotein-a, homocysteine, fibrinogen, C-reactive protein, and interleukin-6. Regression analysis reveals no general statistical relationship between these markers and coronary blood flow as measured by myocardial perfusion imaging. However, when changes in indices are considered and changes in risk factors are compared with changes in ischemia, blood factor based estimates yield an adjusted R 2 = 0.31, R = 0.57, P

Department

Department of Psychology

Original Publication Date

2-1-2008

DOI of published version

10.1177/0003319707303887

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