Centrally Located Body Fat Is Related To Appetitive Hormones In Healthy Postmenopausal Women

Authors

Laura M. Ritland, Iowa State UniversityFollow
D. Lee Alekel, Iowa State UniversityFollow
Oksana A. Matvienko, University of Northern IowaFollow
Kathy B. Hanson, Iowa State University
Jeanne W. Stewart, Iowa State UniversityFollow
Laura N. Hanson, Iowa State UniversityFollow
Manju B. Reddy, Iowa State UniversityFollow
Marta D. Van Loan, University of California, DavisFollow
Ulrike Genschel, Iowa State UniversityFollow

Document Type

Article

Journal/Book/Conference Title

European Journal of Endocrinology

Volume

158

Issue

6

First Page

889

Last Page

897

Abstract

Objective: Body composition and energy homeostasis are thought to affect the appetitive hormones: adiponectin, leptin, insulin, and ghrelin. This study examined whether centrally located fat and/or overall adiposity were related to these appetitive hormones in healthy postmenopausal women. Design: Overall and regional body composition was assessed by dual-energy X ray absorptiometry in relation to plasma adiponectin, serum leptin, serum insulin, and plasma ghrelin in 242 postmenopausal women. Results: Regression analyses revealed that the androidal-to-gynoidal fat mass ratio (18.0%), age (3.2%), and white blood cell count (1.8%) accounted for 28% of the variability in adiponectin (F = 22.2; P < 0.0001); androidal (waist + hip) fat mass (66.0%), androidal fat mass2 (6.2%), whole-body lean mass (2.2%), and age (0.8%) accounted for 69% of the variability in leptin (F = 102,5; P < 0.0001). Regression analyses revealed that sagittal abdominal diameter (8.4%), glucose (5.4%), white blood cell count (2.6%), and dietary ω-3 fatty acids (2.0%) accounted for 32% of the variability in insulin (F = 20.8; P < 0.0001); waist circumference (12.7%), hip lean mass (2.0%), and white blood cell count (1.9%) accounted for 26% of the variability in ghrelin (F = 20.7; P < 0.0001). Our results indicated that centralized fat mass was the primary contributor to these appetitive hormones in healthy postmenopausal women. Conclusion: Since central adiposity in postmenopausal women was related to appetitive hormones, minimizing weight gain during the menopausal transition may optimize appetitive hormones, thereby facilitating appetite control and weight maintenance. © 2008 Society of the European Journal of Endocrinology.

Department

School of Health, Physical Education, and Leisure Services

Original Publication Date

6-1-2008

DOI of published version

10.1530/EJE-07-0836

Recommended Citation

Ritland, Laura M.; Alekel, D. Lee; Matvienko, Oksana A.; Hanson, Kathy B.; Stewart, Jeanne W.; Hanson, Laura N.; Reddy, Manju B.; Van Loan, Marta D.; and Genschel, Ulrike, "Centrally Located Body Fat Is Related To Appetitive Hormones In Healthy Postmenopausal Women" (2008). Faculty Publications. 2431.
https://scholarworks.uni.edu/facpub/2431