"Centrally Located Body Fat Is Related To Inflammatory Markers In Healt" by Courtney D. Perry, D. Lee Alekel et al.
 

Faculty Publications

Centrally Located Body Fat Is Related To Inflammatory Markers In Healthy Postmenopausal Women

Document Type

Article

Keywords

C-reactive protein, Cardiovascular disease, Fibrinogen, Interleukin-1β, Interleukin-6, Tumor necrosis factor α

Journal/Book/Conference Title

Menopause

Volume

15

Issue

4

First Page

619

Last Page

627

Abstract

Objective: C-reactive protein and fibrinogen are established atherosclerotic cardiovascular disease risk factors. These acute-phase proteins and the proinflammatory cytokines tumor necrosis factor α, interleukin-6, and interleukin-1β may be elevated in obesity and with menopause. The purpose of this multicenter study was to identify whether centrally located fat and/or overall adiposity were related to these inflammatory markers in healthy postmenopausal women. Design: We used dual-energy x-ray absorptiometry to assess overall and regional body composition (fat mass in particular) in 242 postmenopausal women in relation to plasma fibrinogen, serum C-reactive protein, and these proinflammatory cytokines. Results: Multiple regression analyses revealed that 36% of the variability in C-reactive protein (F= 32.4, P ≤ 0.0001) was accounted for by androidal fat mass (16.1%, P ≤ 0.0001), white blood cells (5.6%, P ≤ 0.0001), and age (2.3%, P = 0.0045). Regression analyses revealed that 30% of the variability in fibrinogen (F = 24.5, P ≤ 0.0001) was accounted for by white blood cells (3.1%, P = 0.0015), hip fat mass (2.2%, P = 0.0081), years since menopause (0.9%, P = 0.082), and geographic site (P ≤ 0.0001). Our results indicated that androidal fat mass and hip fat mass contributed to C-reactive protein and fibrinogen, respectively, whereas we found no association between whole-body or regional fat measures and cytokines. Conclusion: Further study is warranted to determine the responsiveness of these acute-phase proteins and cytokines to loss of body fat through exercise and dietary intervention in postmenopausal women. Copyright © 2008 The North American Menopause Society.

Department

School of Health, Physical Education, and Leisure Services

Original Publication Date

7-1-2008

DOI of published version

10.1097/gme.0b013e318159f1a2

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