Faculty Publications

Appetitive Hormones, But Not Isoflavone Tablets, Influence Overall And Central Adiposity In Healthy Postmenopausal Women

Document Type

Article

Keywords

Appetitive hormones, Body composition, Postmenopausal women, Soy isoflavones

Journal/Book/Conference Title

Menopause

Volume

17

Issue

3

First Page

594

Last Page

601

Abstract

OBJECTIVE: One of the multiple health benefits of soy protein or its isoflavones may be their purported favorable effect on body composition. We examined the effect of isoflavones extracted from soy protein on overall and regional body composition, taking into account appetitive hormones as potential mediators, as well as the direct effect on appetitive hormones. METHODS: This randomized, double-blind, placebo-controlled multicenter trial included 229 healthy postmenopausal women (age, 45.8-65 y; body mass index, 24.9 ± 3.0 kg/m) who consumed placebo or soy isoflavone (80 or 120 mg/d) tablets for 12 months. We used intent-to-treat analysis to examine changes in body composition (whole-body lean mass, whole-body fat mass, androidal fat mass, and androidal-to-gynoidal fat mass ratio) and appetitive hormones (insulin, leptin, ghrelin, and adiponectin) in response to treatment. RESULTS: Repeated-measures analysis of variance indicated that soy isoflavone treatment did not exert a significant effect on body composition measures (P value from 0.36 to 0.79) or appetitive hormone concentrations; the inclusion of covariates in statistical models did not alter these results. Independently of treatment, leptin and ghrelin related inversely to each body composition measure (P values from 0.044 to ≤0.0001). Adiponectin related inversely to all fat measures (P values from 0.0004 to

Department

School of Health, Physical Education, and Leisure Services

Original Publication Date

5-1-2010

DOI of published version

10.1097/gme.0b013e3181c92134

Link to Full Text

Comments?

Share

COinS