![Faculty Publications](../../assets/md5images/fe9b2118e3cccfd51902ff91d155eabc.png)
Faculty Publications
Appetitive Hormones, But Not Isoflavone Tablets, Influence Overall And Central Adiposity In Healthy Postmenopausal Women
Document Type
Article
Keywords
Appetitive hormones, Body composition, Postmenopausal women, Soy isoflavones
Journal/Book/Conference Title
Menopause
Volume
17
Issue
3
First Page
594
Last Page
601
Abstract
OBJECTIVE: One of the multiple health benefits of soy protein or its isoflavones may be their purported favorable effect on body composition. We examined the effect of isoflavones extracted from soy protein on overall and regional body composition, taking into account appetitive hormones as potential mediators, as well as the direct effect on appetitive hormones. METHODS: This randomized, double-blind, placebo-controlled multicenter trial included 229 healthy postmenopausal women (age, 45.8-65 y; body mass index, 24.9 ± 3.0 kg/m) who consumed placebo or soy isoflavone (80 or 120 mg/d) tablets for 12 months. We used intent-to-treat analysis to examine changes in body composition (whole-body lean mass, whole-body fat mass, androidal fat mass, and androidal-to-gynoidal fat mass ratio) and appetitive hormones (insulin, leptin, ghrelin, and adiponectin) in response to treatment. RESULTS: Repeated-measures analysis of variance indicated that soy isoflavone treatment did not exert a significant effect on body composition measures (P value from 0.36 to 0.79) or appetitive hormone concentrations; the inclusion of covariates in statistical models did not alter these results. Independently of treatment, leptin and ghrelin related inversely to each body composition measure (P values from 0.044 to ≤0.0001). Adiponectin related inversely to all fat measures (P values from 0.0004 to
Department
School of Health, Physical Education, and Leisure Services
Original Publication Date
5-1-2010
DOI of published version
10.1097/gme.0b013e3181c92134
Recommended Citation
Matvienko, Oksana A.; Alekel, D. Lee; Genschel, Ulrike; Ritland, Laura; Van Loan, Marta D.; and Koehler, Kenneth J., "Appetitive Hormones, But Not Isoflavone Tablets, Influence Overall And Central Adiposity In Healthy Postmenopausal Women" (2010). Faculty Publications. 2106.
https://scholarworks.uni.edu/facpub/2106