Histamine, Histidine Decarboxylase, Endothelial Cells, Hypertension, Microcirculatory Regulation.
Isolated endothelial cells have been shown to have a 15-fold greater histidine decarboxylase activity than adjacent intima-media homogenates. The significance of this is discussed in regard to microcirculatory regulation and atherogenesis. The newly formed histamine is thought to play a role in microcirculatory regulation by acting on "dilator receptors" at the capillary level. The role of histamine in atherogenesis is thought to be mediated through an increased arterial wall permeability. Specifically, the increased permeability is the result of increased endothelial cell pinocytotic activity and endothelial cell contraction. These contractions eventually cause distinct gaps in the endothelium at the inter-endothelial cell junctions. Data concerning histidine decarboxylase activity in hypertensive rat aortas is discussed in relation to measures of aortic permeability.
Proceedings of the Iowa Academy of Science
© Copyright 1974 by the Iowa Academy of Science, Inc.
Yarnal, James R. and Rolek, Dennis F.
"Significance of Endothelial Cell Histidine Decarboxylase Activity,"
Proceedings of the Iowa Academy of Science: Vol. 81:
, Article 12.
Available at: http://scholarworks.uni.edu/pias/vol81/iss3/12