2020 Research in the Capitol

Presentation Type

Open Access Poster Presentation

Abstract

The mitochondrion, an organelle responsible for generating cellular energy, is unlike the majority of organelles in animal cells. Because of its symbiotic origins, the mitochondrion contains its own genetic information (mtDNA) that is predominantly maternally inherited. In most animals, the mitochondrial DNA is arranged in one circular chromosome containing 13 protein coding genes, 22 tRNAs and two rRNAs. In Geomydoecus aurei, a chewing louse, these same genes have been disbursed among at least 13 independent minicircle chromosomes. We have worked to map this atypical genome to gain insights into its development and to further understanding of genomic rearrangements in this important genetic material. Identification and characterization of the unique nature of this mtDNA may lead to a better understanding of many debilitating disorders associated with mitochondrial dysfunction.

Start Date

24-3-2020 11:00 AM

End Date

24-3-2020 2:30 PM

Event Host

University Honors Programs, Iowa Regent Universities

Faculty Advisor

James Demastes

Department

Department of Biology

File Format

application/pdf

Share

COinS
 
Mar 24th, 11:00 AM Mar 24th, 2:30 PM

Characterization of a New mtDNA Minicircle in a Chewing Louse, Geomydoecus aurei

The mitochondrion, an organelle responsible for generating cellular energy, is unlike the majority of organelles in animal cells. Because of its symbiotic origins, the mitochondrion contains its own genetic information (mtDNA) that is predominantly maternally inherited. In most animals, the mitochondrial DNA is arranged in one circular chromosome containing 13 protein coding genes, 22 tRNAs and two rRNAs. In Geomydoecus aurei, a chewing louse, these same genes have been disbursed among at least 13 independent minicircle chromosomes. We have worked to map this atypical genome to gain insights into its development and to further understanding of genomic rearrangements in this important genetic material. Identification and characterization of the unique nature of this mtDNA may lead to a better understanding of many debilitating disorders associated with mitochondrial dysfunction.