Presidential Scholars Theses (1990 – 2006)
Awards/Availabilty
Open Access Presidential Scholars Thesis
First Advisor
Robert J. Simpson
Keywords
Estrogen--Physiological effect; Osteoporosis--Treatment;
Abstract
If nuclear binding sites for estrogens exist in bone cells, then the origin of estrogen-deficiency-induced osteopenia may be at the level of bone matrix protein synthesis. Since collagen is the most abundant protein in the bone matrix, and since hydroxyproline is an imino acid nearly exclusive to collagen, a monitoring of the metabolism of hydroxyproline in ovariectomized and estrogen treated rats may provide insight into the patterns of estrogen-deficiency-induced osteopenia. The purpose of our study was to test the hypothesis that ovariectomy will increase urinary hydroxyproline excretion in the rat and that this increase will be reversed by estrogen treatment therapy.
Date of Award
1991
Department
Department of Biology
Presidential Scholar Designation
A paper submitted in partial fulfillment of the requirements for the designation Presidential Scholar.
Date Original
5-7-1991
Object Description
1 PDF file (17 pages)
Date Digital
4-28-2017
Copyright
©1991 Gregg Horras
Type
document
Language
EN
File Format
application_pdf
Recommended Citation
Horras, Gregg, "Patterns of hydroxyproline excretion in ovariectomized and estrogen treated rats" (1991). Presidential Scholars Theses (1990 – 2006). 5.
https://scholarworks.uni.edu/pst/5
