Faculty Publications
Document Type
Article
Publication Version
Published Version
Keywords
cognitive function, creatine, functional near-infrared spectroscopy, oxygenated hemoglobin, prefrontal cortex
Journal/Book/Conference Title
Brain Sciences
Volume
13
Issue
9
Abstract
To determine if creatine (Cr) supplementation could influence cognitive performance and whether any changes were related to changes in prefrontal cortex (PFC) activation during such cognitive tasks, thirty (M = 11, F = 19) participants were evenly randomized to receive supplementation with Cr (CR10:10 g/day or CR20:20 g/day) or a placebo (PLA:10 g/day) for 6 weeks. Participants completed a cognitive test battery (processing speed, episodic memory, and attention) on two separate occasions prior to and following supplementation. Functional near-infrared spectroscopy (fNIRS) was used to measure PFC oxyhemoglobin (O2Hb) during the cognitive evaluation. A two-way repeated measures ANOVA was used to determine the differences between the groups and the timepoints for the cognitive performance scores and PFC O2Hb. In addition, a one-way ANOVA of % change was used to determine pre- and post-differences between the groups. Creatine (independent of dosage) had no significant effect on the measures of cognitive performance. There was a trend for decreased relative PFC O2Hb in the CR10 group versus the PLA group in the processing speed test (p = 0.06). Overall, six weeks of Cr supplementation at a moderate or high dose does not improve cognitive performance or change PFC activation in young adults.
Department
Department of Kinesiology
Original Publication Date
9-1-2023
Object Description
1 PDF File
DOI of published version
10.3390/brainsci13091276
Repository
UNI ScholarWorks, Rod Library, University of Northern Iowa
Copyright
© 2023 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Language
en
File Format
application/pdf
Recommended Citation
Moriarty, Terence; Bourbeau, Kelsey; Dorman, Katie; Runyon, Lance; Glaser, Noah; Brandt, Jenna; Hoodjer, Mallory; Forbes, Scott C.; and Candow, Darren G., "Dose–Response of Creatine Supplementation on Cognitive Function in Healthy Young Adults" (2023). Faculty Publications. 5463.
https://scholarworks.uni.edu/facpub/5463
Comments
First published in Brain Sciences, v13I9 (Sep 2023) published by MDPI. DOI: https://doi.org/10.3390/brainsci13091276