Faculty Publications

Title

The effects of genetic screening and assortative mating on lethal recessive-allele frequencies and homozygote incidence

Document Type

Article

Journal/Book/Conference Title

American Journal of Human Genetics

Volume

41

Issue

4

First Page

671

Last Page

677

Abstract

The widespread use of genetic screening, along with mating and reproductive patterns reflecting that information, can significantly alter the genetic structure of populations. Both allele frequencies and mortality could be significantly reduced if carriers of lethal recessive alleles were withdrawn from the mating pool. But schemes to mask deleterious alleles in heterozygous condition could significantly increase the deleterious-allele frequencies while resulting in only a slight reduction in mortality. The immediate and equilibrium consequences of such mating strategies may be quite disparate.

Original Publication Date

12-1-1987

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