Presidential Scholars Theses (1990 – 2006)

Awards/Availabilty

Open Access Presidential Scholars Thesis

First Advisor

Robert J. Simpson

Keywords

Estrogen--Physiological effect; Osteoporosis--Treatment;

Abstract

If nuclear binding sites for estrogens exist in bone cells, then the origin of estrogen-deficiency-induced osteopenia may be at the level of bone matrix protein synthesis. Since collagen is the most abundant protein in the bone matrix, and since hydroxyproline is an imino acid nearly exclusive to collagen, a monitoring of the metabolism of hydroxyproline in ovariectomized and estrogen treated rats may provide insight into the patterns of estrogen-deficiency-induced osteopenia. The purpose of our study was to test the hypothesis that ovariectomy will increase urinary hydroxyproline excretion in the rat and that this increase will be reversed by estrogen treatment therapy.

Date of Award

1991

Department

Department of Biology

Presidential Scholar Designation

A paper submitted in partial fulfillment of the requirements for the designation Presidential Scholar.

Date Original

5-7-1991

Object Description

1 PDF file (17 pages)

Date Digital

4-28-2017

Copyright

©1991 Gregg Horras

Type

document

Language

EN

File Format

application_pdf

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