2018 Research in the Capitol

Title

Synthesis and Coupling Schemes of Naphthalimide Compounds with Target Drugs

Presentation Type

Poster Presentation

Abstract

The target compound has three major parts, the naphthalimide core with tail, a linker, and the target drug. The target compound can be used for localized drug delivery by utilizing the photoactive properties of the core and a hydrolysis reaction in the body. Our research focused on the synthesis of target compound. There were two reactions schemes used during this research. The original scheme followed steps to synthesize the naphthalimide core with the tail and linker portion of the compound first, then it is coupled with the target drug. The second scheme, or modified scheme, was developed during this project to more effectively synthesize the target product. In the modified scheme, first half of the linker is attached to the naphthalimide core with the tail, then the other half is attached to the target drug, and finally the two halves of the linker are attached.

Start Date

3-4-2018 11:30 AM

End Date

3-4-2018 1:30 PM

Event Host

University Honors Programs, Iowa Regent Universities

Faculty Advisor

Jeff Elbert

Department

Department of Chemistry and Biochemistry

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Apr 3rd, 11:30 AM Apr 3rd, 1:30 PM

Synthesis and Coupling Schemes of Naphthalimide Compounds with Target Drugs

The target compound has three major parts, the naphthalimide core with tail, a linker, and the target drug. The target compound can be used for localized drug delivery by utilizing the photoactive properties of the core and a hydrolysis reaction in the body. Our research focused on the synthesis of target compound. There were two reactions schemes used during this research. The original scheme followed steps to synthesize the naphthalimide core with the tail and linker portion of the compound first, then it is coupled with the target drug. The second scheme, or modified scheme, was developed during this project to more effectively synthesize the target product. In the modified scheme, first half of the linker is attached to the naphthalimide core with the tail, then the other half is attached to the target drug, and finally the two halves of the linker are attached.