Administration of the antithyroid drug, propylthiouracil (PTU), to albino male rats at the dietary level of 0.1 % PTU is accompanied by a decrease in growth rate and a decrease in the oxygen consumption rate. After the initial administration of PTU, prolonged treatment with the drug did not further lower the oxygen consumption rate. The ratios of organ weight to body weight for the testes, stomach, thyroid, eyes, pituitary, and brain were found to be larger in the treated rats than in the untreated controls. The organ weight to body weight ratios of the spleen, liver, kidneys, and heart were smaller in the PTU treated rats than in the untreated controls examined.
Proceedings of the Iowa Academy of Science
©1969 Iowa Academy of Science, Inc.
Shold, A. James
"Anatomic and Physiologic Effects of the Antithyroid Drug, Propylthiouracil, on Rats,"
Proceedings of the Iowa Academy of Science, 76(1), 361-367.
Available at: https://scholarworks.uni.edu/pias/vol76/iss1/47