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Authors

Lenore Southam

Document Type

Research

Abstract

Silastic (dimethylpolysiloxane) capsules containing megestrol acetate (6- methyl-17-∝-acetoxypregna-4, 6- diene-3, 20-dione) were implanted subcutaneously in mature female rats. The effects of megestrol on the ovary, on fertility, on body weight, on adrenal weight, and on physical activity were observed. Megestrol acetate did not inhibit ovulation or fertility, and did not reduce ovarian weight; thus it did not have an anti-gonadotrophic effect at the dosages used. It affected vaginal cytology in a typical progestational fashion producing a constant diestrus or mixed cell smear. Body weight increased during treatment and remained fairly constant after treatment stopped. Adrenal weight decreased during treatment and returned to normal after treatment stopped. These two effects may contribute to a decreased physical activity observed in some rats. Continuing obesity after treatment stopped may account for the failure of some rats to regain normal activity. Obesity may also be a factor in the inhibition of mating behavior observed in some of the animals.

Publication Date

1968

Journal Title

Proceedings of the Iowa Academy of Science

Volume

75

Issue

1

First Page

296

Last Page

300

Copyright

© Copyright 1968 by the Iowa Academy of Science, Inc.

Language

EN

File Format

application/pdf

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