Several investigators have suggested that the nucleic acid content of mouse liver varied with the estrus cycle. Nucleic acids were extracted with trichloroacetic acid and ethanol. The quantity of DNA and RNA was determined with a spectrophotometer. No significant differences were observed in the quantity of DNA or RNA throughout the estrus cycle. Diversity in the amount of nucleic acids present among the livers of non-litter mates was one-third greater that that among litter mates. In studies of the nucleio acid content of mouse liver, little is gained by controlling the estrus cycle, but using litter mates is suggested to demonstrate small fluctuations.
Proceedings of the Iowa Academy of Science
©1965 Iowa Academy of Science, Inc.
Wolfe, Allan F.
"A Quantitative Study of the DNA and RNA in the Livers of Albino Mice During the Estrus Cycle,"
Proceedings of the Iowa Academy of Science, 72(1), 539-544.
Available at: https://scholarworks.uni.edu/pias/vol72/iss1/77