A study of the effects of propylthiouracil on the rat thymus showed histological changes in that tissue. The overall weight of the thymus tissue was reduced in comparison to the thymus weight of the control group. Histologically the thymus of the PTU group showed decreased width in the cortex with fewer lymphocytes and thymic corpuscles in the medullary portion. There appeared to be an intermediate area between the cortex and medulla rather than the distinct demarcation seen between the cortex and medulla of the normal rat thymus. The results observed in these tissues may indicate a retardation in the maturation of the thymus rather than thymic involution. Further histological studies must be made on the changes of the normal rat thymus from birth to adulthood in order to determine the extent of deviation from normal thymic growth as was observed in this experiment.
Proceedings of the Iowa Academy of Science
©1965 Iowa Academy of Science, Inc.
Conklin, Maybelle G.
"A Pilot Study of the Thymus of Propylthiouracil-treated Rats,"
Proceedings of the Iowa Academy of Science, 72(1), 432-443.
Available at: https://scholarworks.uni.edu/pias/vol72/iss1/64