The anti-thyroid drug Tapazole, when fed to white rats at the dietary level of 0.1% Tapazole in finely ground laboratory meal, produces changes in body weight, thyroid weight and in the histological composition of the thyroid. Histological examination shows that the affected thyroids have undergone hypertrophy and hyperplasia. Tapazole does not seem to affect rat hearts or adrenals.
Proceedings of the Iowa Academy of Science
©1965 Iowa Academy of Science, Inc.
Collier, Wade L.
"The Histological Effects of Tapazole on Rat Thyroids, Hearts, and Adrenals,"
Proceedings of the Iowa Academy of Science, 72(1), 425-432.
Available at: https://scholarworks.uni.edu/pias/vol72/iss1/63