The anti-thyroid drug, propylthiouracil (PTU), when fed to female rats at the dietary level of 0.1% has a slight effect on the average number of young per litter if administered during the preconception period or gestation but if administered continuously during these periods results in a much lower litter size. PTU treatment of mothers during lactation results in cretin-like young and poor survival rates during lactation and after weaning. Ratios of thyroid weight to body weight indicate transfer of PTU to young during gestation and lactation.
Proceedings of the Iowa Academy of Science
©1962 Iowa Academy of Science, Inc.
Cook, Kenneth M.
"The Influence of the Antithyroid Drug, Propylthiouracil, on Gestation and Lactation in Rats,"
Proceedings of the Iowa Academy of Science, 69(1), 624-635.
Available at: https://scholarworks.uni.edu/pias/vol69/iss1/95