Systolic and diastolic blood pressures were lowered in male rats by treatment with 0.1 percent dietary propylthiouracil for a period of ten to twelve weeks. At the best comparison levels systolic pressure measurements of experimental rats dropped 15.0 percent by the indirect method and 26.9 percent by the direct method when compared to the levels of control rats. The diastolic values of experimental animals dropped 18.3 percent as measured by the indirect method and 28.9 percent as measured by the direct method when compared to controls. Thus, the hypothyroid state induced by the drug propylthiouracil is accompanied by reduced systolic and diastolic blood pressures.
Proceedings of the Iowa Academy of Science
©1960 Iowa Academy of Science, Inc.
"Direct and Indirect Measurements of Arterial Blood Pressure in Normal and Propylthiouracil-treated Rats,"
Proceedings of the Iowa Academy of Science, 67(1), 471-479.
Available at: https://scholarworks.uni.edu/pias/vol67/iss1/59