The antithyroid drug, propylthiouracil (PTU), when fed to white rats at the dietary level of 0.1 percent PTU in finely ground laboratory chow for ten weeks prior to mating, does not affect the ability of either male or female rats to reproduce. All metabolic evidences examined indicate a lower metabolism under the influence of PTU. The PTU dietary treatment was ceased at conception of PTU females. Characteristics of the offspring did not differ from those produced by mothers maintained on normal laboratory chow throughout the experiment.
Proceedings of the Iowa Academy of Science
©1960 Iowa Academy of Science, Inc.
Cook, Kenneth M.
"The Influence of the Antithyroid Drug, Propylthiouracil, on Reproduction In Rats,"
Proceedings of the Iowa Academy of Science, 67(1), 463-470.
Available at: https://scholarworks.uni.edu/pias/vol67/iss1/58