The allyl group was substituted on the side chains of benzedrine and ephedrine in the belief that these derivatives would antagonize the parent compounds. Their antagonistic effect was clearly demonstrated; the action was believed to be due to reaction at the receptors in the muscles.
Proceedings of the Iowa Academy of Science
©1960 Iowa Academy of Science, Inc.
Fox, Ellen; Lynch, Elaine; Theisen, Myna; and Christine, M. Marguerite
"Allyl Derivatives of Sympathomimetic Amines,"
Proceedings of the Iowa Academy of Science, 67(1), 206-209.
Available at: https://scholarworks.uni.edu/pias/vol67/iss1/29